4-Bromo-2-(trifluoromethoxy)aniline → 4-(1-methyl-1H-pyrazol-4-yl)-2-(trifluoromethoxy)aniline

HRID 1480853Notes

Reaction equation

HRID 1480853 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:10]=[C:9](Br)[CH:8]=[CH:7][C:5]=1[NH2:6].[CH3:14][N:15]1[CH:19]=[C:18](B2OC(C)(C)C(C)(C)O2)[CH:17]=[N:16]1>>[CH3:14][N:15]1[CH:19]=[C:18]([C:9]2[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([O:3][C:2]([F:13])([F:12])[F:1])[CH:10]=2)[CH:17]=[N:16]1

Participants

3

Reactant 2

HCID 7373824-Bromo-2-(trifluoromethoxy)anilineHCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 1

HCID 899960394-(1-methyl-1H-pyrazol-4-yl)-2-(trifluoromethoxy)aniline

Procedure

The title compound was prepared according to the method described for Preparation 98 using 2-trifluoromethoxy-4-bromoaniline and 1-methylpyrazole-4-boronic acid pinacol ester.

Sources & evidence

ORD record
ord-76c79d6dd9684d1a942d241db7836768
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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