2-Methoxy-2-methylpropan-1-amine → N-(2-Methoxy-2-methylpropyl)-2-(methylthio)pyrido[3,4-d]pyrimidin-8-amine

HRID 1480855Notes

Reaction equation

HRID 1480855 reaction equation
[CH3:1][O:2][C:3]([CH3:7])([CH3:6])[CH2:4][NH2:5].Cl[C:9]1[C:14]2[N:15]=[C:16]([S:19][CH3:20])[N:17]=[CH:18][C:13]=2[CH:12]=[CH:11][N:10]=1>>[CH3:1][O:2][C:3]([CH3:7])([CH3:6])[CH2:4][NH:5][C:9]1[C:14]2[N:15]=[C:16]([S:19][CH3:20])[N:17]=[CH:18][C:13]=2[CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 117891412-Methoxy-2-methylpropan-1-amineHCID 899960258-Chloro-2-(methylthio)pyrido[3,4-d]pyrimidine

Product 1

HCID 89995997N-(2-Methoxy-2-methylpropyl)-2-(methylthio)pyrido[3,4-d]pyrimidin-8-amine

Procedure

The title compound was prepared according to the method described for Preparation 175 using 2-methoxy-2-methylpropan-1-amine and 8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidine (Preparation 33). The residue was purified by elution through an SCX-2 column using 50% methanol in chloroform followed by 50% chloroform in 7N NH3/MeOH followed by silica gel column chromatography eluting with EtOAc.

Workup

  1. customThe residue was purified by elution through an SCX-2 column
  2. washeluting with EtOAc

Sources & evidence

ORD record
ord-a19b87ed6f834ae8870027873c8170d8
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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