HCID 89996095, compound → HCID 89748354, compound

HRID 1480883Notes

Reaction equation

HRID 1480883 reaction equation
[F:1][CH:2]([F:19])[O:3][C:4]1[CH:5]=[C:6]([C:13]2[CH:14]=[N:15][N:16]([CH3:18])[CH:17]=2)[CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O>CCO>[F:19][CH:2]([F:1])[O:3][C:4]1[CH:5]=[C:6]([C:13]2[CH:14]=[N:15][N:16]([CH3:18])[CH:17]=2)[CH:7]=[CH:8][C:9]=1[NH2:10]

Participants

3

Reactant 1

HCID 89996095HCID 89996095, compound

Product 1

HCID 89748354HCID 89748354, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the method described for Preparation 158 using 4-(3-(difluoromethoxy)-4-nitrophenyl)-1-methyl-1H-pyrazole (Preparation 214) in EtOH for 40 minutes. The residue was purified by elution through an SCX-2 column using 50% methanol in chloroform followed by 50% chloroform in 7N NH3/MeOH.

Workup

  1. customThe residue was purified by elution through an SCX-2 column

Sources & evidence

ORD record
ord-4ed097135e384a6b91cc85175bed956c
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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