2-Cyano-2-propyl-pentanoic acid tert-butyl ester → Tert-butyl 2-(aminomethyl)-2-propylpentanoate

Participants

Reaction Steps

A mixture of 2-cyano-2-propyl-pentanoic acid tert-butyl ester (6.87 g) and Raney Ni (4 mL in water) in MeOH (200 mL) was stirred at rt under H2 atmosphere (balloon) overnight. Then the reaction mixture was filtered over Celite pad, filtrate was concentrated to give the desired product (4.92 g). 1H NMR in CDCl3, δ in ppm: 2.76 (s, 2H), 1.44 (s, 9H), 1.5-1.1 (m, 8H), 0.91 (t, 6H, J=7.0 Hz).

Provenance & Evidence