反应详情

A mixture of 4-hydroxy-7-(pyridin-3-yloxy)-isoquinoline-3-carboxylic acid ethyl ester (26 mg), 3-amino-propionic acid (30 mg) and NaOMe (0.50 mL, 0.5 M solution in MeOH) was microwaved at 130° C. for 1 h; then cooled, concentrated, residue was dissolved in water, acidified with 2 M HCl; solids were collected via filtration, washed with water and air dried to give the desired product (25 mg). LC MS ESI: 354 (M+1)+.

1. customwas microwaved at 130° C. for 1 h
2. temperaturethen cooled
3. concentrationconcentrated
4. dissolutionresidue was dissolved in water
5. filtrationsolids were collected via filtration
6. washwashed with water and air
7. customdried