Tert-butyl 1-cyanocyclobutane-1-carboxylate → Tert-butyl 1-(aminomethyl)cyclobutane-1-carboxylate

Participants

Reaction Steps

A mixture of 1-cyano-cyclobutanecarboxylic acid tert-butyl ester (6.58 g) and Raney Ni (10 mL in water) in MeOH (250 mL) was stirred at rt under H2 atmosphere (balloon) overnight. Then the reaction mixture was filtered over Celite pad, filtrate was concentrated to give the desired product (5.59 g). 1H NMR in CDCl3, δ in ppm: 2.94 (s, 2H), 2.4-2.2 (m, 2H), 2.0-1.8 (m, 4H), 1.46 (s, 9H).

Provenance & Evidence