Methyl 4-methyl-4-nitropentanoate → HCID 24973904, compound

HRID 1481023Notes

Reaction equation

HRID 1481023 reaction equation
[CH3:1][C:2]([N+:10]([O-])=O)([CH3:9])[CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]>CC(O)=O.[Pd]>[NH2:10][C:2]([CH3:9])([CH3:1])[CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 1

HCID 247995Methyl 4-methyl-4-nitropentanoate

Product 1

HCID 24973904HCID 24973904, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

Methyl 4-methyl-4-nitropentanoate (0.8 g, 4.57 mmol) (Moffett (1963) Org. Syn. Coll. 4:652) and Pd/C (1 g, 10% by weight) were suspended in AcOH (15 mL). The resulting mixture was stirred under a hydrogen atmosphere at room temperature for 16 hours. The reaction mixture was then filtered through a pad of celite. The filtrate was concentrated and the crude was used in the subsequent step without further purification. MS: (+) m/z 146.12.91 (M+1).

Workup

  1. filtrationThe reaction mixture was then filtered through a pad of celite
  2. concentrationThe filtrate was concentrated
  3. customthe crude was used in the subsequent step without further purification

Sources & evidence

ORD record
ord-461d89a0582c4b208258f52effce0d45
Source dataset
uspto-grants-2016_08
Patent number
US09409892B2

Reaction notes

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