Sodium Thiosulfate → HCID 89813056, compound

Participants

Reaction Steps

To a solution of (S)-Methyl 4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoate (54 mg, 0.13 mmol) in anhydrous CH2Cl2 (5 mL) was added Dess-Martin periodinane (65 mg, 0.15 mmol). After stirring for 1 hour at room temperature, 2% Na2S2O3 (6 mL) was added and the resulting mixture was stirred at room temperature for 30 minutes. The layers were separated and the organic layer was washed with H2O, dried over MgSO4, concentrated, and purified by flash chromatography (0-20% EtOAc/CH2Cl2) to give the title compound in 34 mg. MS: (−) m/z 418.24 (M−1).

Provenance & Evidence