HCID 549238, compound → HCID 21218586, compound

HRID 1481044Notes

Reaction equation

HRID 1481044 reaction equation
[C:1]([CH:3]([CH2:8][CH3:9])[C:4]([O:6][CH3:7])=[O:5])#[N:2]>CCO.[Ni]>[CH3:7][O:6][C:4](=[O:5])[CH:3]([CH2:1][NH2:2])[CH2:8][CH3:9]

Participants

4

Reactant 1

HCID 549238HCID 549238, compound

Product 1

HCID 21218586HCID 21218586, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

To a slurry of Raney-Ni (1.9 g, 50% in H2O, rinsed 3 times with EtOH before use) in EtOH (20 mL) was added methyl 2-cyanobutanoate (200 mg, 1.57 mmol). The resulting mixture was stirred under a hydrogen atmosphere at room temperature for 20 hours. The liquid was then carefully decanted into another flask and the metal was washed twice with EtOH. The combined EtOH solution was concentrated in vacuo to give the title compound in 200 mg, which was used in the subsequent step without further purification.

Workup

  1. customThe liquid was then carefully decanted into another flask
  2. washthe metal was washed twice with EtOH
  3. concentrationThe combined EtOH solution was concentrated in vacuo

Sources & evidence

ORD record
ord-539df67515f84920ad419563cd5e74d0
Source dataset
uspto-grants-2016_08
Patent number
US09409892B2

Reaction notes

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