HCID 131736615, compound → HCID 89813006, compound

Participants

Reaction Steps

A mixture of tert-butyl (2S,3S,αS)-3-(N-benzyl-N-α-methylbenzylamino)-2-methyl-butyrate (245 mg, 0.668 mmol) and 20% Pd(OH)2 on carbon (100 mg) in EtOH (10 mL) was stirred under H2 atmosphere (1 atm) for 48 h, then filtered through a pad of Celite. The filtrate was concentrated to give 86 mg of the title compound, which was used in the next step without purification. 1H NMR (CDCl3, 200 MHz): δ=5.5 (broad), 3.45-3.65 (m, 1H), 2.60-2.75 (m, 1H), 1.46 (s, 9H), 1.36 (d, 3H, J=6.6 Hz), 1.26 (d, 3H, J=7.0 Hz).

Provenance & Evidence