HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenylurea → 7-[3-(4-Fluoro-phenyl)-ureido]-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenylurea | HCID 12612 | — |
| Reactant | Ethyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate | HCID 89813095 | — |
| Product | 7-[3-(4-Fluoro-phenyl)-ureido]-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester | HCID 89813160 | — |
Reaction Steps
7-[3-(4-Fluoro-phenyl)-ureido]-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester was prepared from 7-Bromo-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester under conditions analogous to Example 116(a) using 4-Fluorophenylurea. MS ESI(+) m/e: 370.0130 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409892B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-1bba88b4ab274390a99fa59c39f5fa00 |
| Source note | uspto-grants-2016_08 |