HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-5-(tributylstannyl)-3-(trifluoromethyl)-1H-pyrazole → 4-Hydroxy-1-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-5-(tributylstannyl)-3-(trifluoromethyl)-1H-pyrazole | HCID 12056710 | — |
| Reactant | Methyl 1-bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate | HCID 89813003 | — |
| Product | 4-Hydroxy-1-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester | HCID 136610997 | — |
Reaction Steps
4-Hydroxy-1-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester was prepared from 1-bromo-4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester using 1-methyl-5-tributylstannanyl-3-trifluoromethyl-1H-pyrazole under conditions analogous to Example 132(a). MS ESI(−) m/e: 442.0128 (M−1.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409892B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-02059afa101340739553f7b30ea46dfa |
| Source note | uspto-grants-2016_08 |