反应详情

To a solution of 4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester (1.08 g, 3.66 mmol) in flask was added 4-Amino-butyric acid (3.77 g, 36.6 mmol) and NaOMe (58 mL, 29.28 mmol, 0.5 M solution in MeOH). The reaction mixture was allowed to reflux. After 24 h, the mixture was cooled to rt, and concentrated in vacuo to give residue as a solid. The solid was dissolved in water (50 mL), extracted with CH2Cl2 (2×20 mL). The aqueous solution was acidified by 1N HCl solution, filtered, washed with water, dried to give 1.32 g of title of the compound as a white solid: MS (m/z) 367.0 (M+1)+.

1. temperatureto reflux
2. concentrationconcentrated in vacuo
3. customto give residue as a solid
4. extractionextracted with CH2Cl2 (2×20 mL)
5. filtrationfiltered
6. washwashed with water
7. customdried