反应详情

To a solution of 4-[(4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-butyric acid (1.32 g, 3.6 mmol) in MeOH (7.2 mL) was added 10% sulfuric acid. The reaction mixture was stirred at reflux for 20 hours. After cooled to rt, the solvent was concentrated in vacuo as a oil and purified by silica gel chromatography over silica gel, eluting with 15-75% EtOAc/hexanes to give product (900 mg) as a colorless oil: MS (m/z) 381.0 (M+1)+.

1. temperatureat reflux for 20 hours
2. concentrationthe solvent was concentrated in vacuo as a oil
3. custompurified by silica gel chromatography over silica gel
4. washeluting with 15-75% EtOAc/hexanes