Benzylurea → 7-(3-Benzyl-ureido)-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

HRID 1481207Notes

Reaction equation

HRID 1481207 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([C:18]#[N:19])[C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11](Br)[CH:10]=2)=[O:5])[CH3:2].[CH2:20]([NH:27][C:28]([NH2:30])=[O:29])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([C:18]#[N:19])[C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([NH:30][C:28]([NH:27][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:29])[CH:10]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 10853BenzylureaHCID 898128697-Bromo-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

Product 1

HCID 898131227-(3-Benzyl-ureido)-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

Procedure

7-(3-Benzyl-ureido)-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester was prepared from 7-bromo-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester under conditions analogous to Example 116(a) using benzylurea. MS ESI(+) m/e: 391.0935 (M+1).

Sources & evidence

ORD record
ord-cb0c1f0967ca4b9c9bebd40ceb5ca59f
Source dataset
uspto-grants-2016_08
Patent number
US09409892B2

Reaction notes

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