(2-Chloro-5-nitro-pyrimidin-4-yl)-(4-methoxy-phenyl)-amine → 2-Chloro-N4-(4-methoxyphenyl)pyrimidine-4,5-diamine

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Reaction Steps

A solution of 1.86 g (6.64 mmol) (2-chloro-5-nitro-pyrimidin-4-yl)-(4-methoxy-phenyl)-amine (from example 1) in 20 ml THF is hydrogenated with 1.0 g sponge-nickel as catalyst at room temperature and under atmospheric pressure. The catalyst is filtered off; the filtrate is evaporated and dried under vacuum giving 2-chloro-N4-(4-methoxy-phenyl)-pyrimidine-4,5-diamine as grey solid; HPLC/MS (A): 1.63 min, [M+H] 251;

Provenance & Evidence