1-(Tetrahydro-2H-pyran-4-YL)-1H-pyrazol-4-amine → HCID 71667334, compound

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Reaction Steps

A solution of 74.9 mg (0.30 mmol) 5-chloro-3-(4-fluoro-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 60.2 mg (0.36 mmol) 1-(tetrahydro-pyran-4-yl)-1H-pyrazol-4-ylamine in 0.5 ml 2-methoxy-ethanol is stirred for 4 hours at 90° C. The reaction mixture is cooled to room temperature. The solvent is partially removed under vacuum and the residue is purified by preparative HPLC yielding “A20” as brown amorphous solid; HPLC/MS (B): 2.1 min, [M+H] 381;

Provenance & Evidence