Sulfuric Acid → HCID 71667335, compound

Participants

Reaction Steps

A suspension of 80 mg (0.28 mmol) N2,N4-bis-(1-methyl-1H-pyrazol-4-yl)-pyrimidine-2,4,5-triamine in 23 ml water is treated with 4 ml concentrated sulfuric acid and then with 39 mg (0.56 mmol) sodium nitrite. The reaction mixture is stirred for 90 minutes at room temperature. The reaction mixture is partitioned between water and dichloromethane. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica gel column with methanol/dichloromethane as eluent giving “A21” as off-white crystals; HPLC/MS (A) 1.42 min, [M+H] 297;

Provenance & Evidence