3-Chloro-2,6-difluorobenzaldehyde → 1-(6-Bromo-3-chloro-2-fluorophenyl)prop-2-en-1-one

HRID 1481261Notes

Reaction equation

HRID 1481261 reaction equation
Cl[C:2]1C(F)=C(C(F)=C[CH:9]=1)C=O.[Br:12][C:13]1[C:18]([CH:19]=[O:20])=[C:17]([F:21])[C:16]([Cl:22])=[CH:15][CH:14]=1>>[Br:12][C:13]1[C:18]([C:19](=[O:20])[CH:2]=[CH2:9])=[C:17]([F:21])[C:16]([Cl:22])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7363383-Chloro-2,6-difluorobenzaldehydeHCID 569717406-Bromo-3-chloro-2-fluorobenzaldehyde

Product 1

HCID 867102181-(6-Bromo-3-chloro-2-fluorophenyl)prop-2-en-1-one

Procedure

1-(6-Bromo-3-chloro-2-fluorophenyl)prop-2-en-1-one was prepared using a procedure analogous to intermediate 1 except that 3-chloro-2,6-difluorobenzaldehyde was replaced with 6-bromo-3-chloro-2-fluorobenzaldehyde. 1H NMR (500 MHz, CDCl3) δ 7.33-7.41 (m, 2H), 6.64 (dd, J=17.6, 10.2 Hz, 1H), 6.25 (d, J=10.7 Hz, 1H), 6.07 (d, J=17.6 Hz, 1H).

Sources & evidence

ORD record
ord-5b35ab0997ed4faebecb73357fb3ac77
Source dataset
uspto-grants-2016_08
Patent number
US09409908B2

Reaction notes

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