Hydrochloric Acid → HCID 131736633, compound

Participants

Reaction Conditions

Reaction Steps

To a round bottom flask was added 151D (35 mg, 0.040 mmol) and MeOH (2 mL). The reaction was cooled to 0° C. and sodium methoxide (26.2 mg, 0.121 mmol) was added to the reaction. The reaction was stirred at 0° C. for 10 min. Then the reaction was quenched by 1N HCl (0.081 mL, 0.081 mmol). The reaction was then partitioned between EtOAc (25 mL) and NaHCO3 (10 mL). The organic layer was separated, washed with saturated NaCl solution (10 mL), dried over MgSO4, filtered and concentrated to give methyl 151E (22 mg, 0.031 mmol, 76% yield) as a white solid. MS (ESI) m/z: 710.3 (M+H)+.

Provenance & Evidence