Sodium Methoxide → HCID 131736638, compound

Participants

Reaction Steps

To the solution of 227B (1.35 g, 1.27 mmol) in MeOH (36.3 ml) at 0° C. was added sodium methoxide (25% wt in MeOH) (1.454 ml, 6.36 mmol). The reaction was warmed to RT. After 1 h, the reaction mixture was concentrated. The residue dissolved in EtOAc, washed twice with 1.5 dipotassium phosphate solution (aq.), brine, dried over Na2SO4, filtered, and concentrated. The crude residue was purified by normal phase column chromatography to give 227C (765 mg, 76%) as a tan solid. MS (ESI) m/z: 792/794 (M+H)+, bromine isotope.

Provenance & Evidence