Lithium hydroxide, monohydrate → HCID 117818950, compound

Participants

Reaction Steps

To a solution of 3-fluoro-2,3-dihydrofuro[2,3-b]pyridine-3-carboxylic acid methyl ester (0.30 mmol) in 3 mL EtOH and 2 mL MeOH was added a solution of LiOH.H2O (0.33 mmol) in 1 mL H2O. The reaction was stirred at RT for 50 min. The reaction mixture was diluted with 10 mL EtOAc and extracted twice with water. The water phase was acidified to pH 3 and extracted 3 times with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to obtain the desired product as white solid.

Provenance & Evidence