HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2,4-Dichloro-6-fluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 2,4-Dichloro-6-fluorobenzamide | HCID 22478160 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-Dichloro-6-fluorobenzonitrile | HCID 56604255 | — |
Reaction Steps
To a solution of 2,4-dichloro-6-fluorobenzamide (5.07 mmol) (US 20060178386) in 74 mL DCM were added Et3N (15.2 mmol) followed by TFAA (10.1 mmol) at 0° C. After 30 min, water was added, the organic layer was separated and concentrated in vacuo. Purification with CC (KP-SIL™ from Biotage) using Hept/EtOAc ( 4/1 to ⅓) gives the desired compound as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409917B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-51a6f22e51b14da2a8ef772e6f8e3a23 |
| Source note | uspto-grants-2016_08 |