Morpholine → 2-(6-Methoxypyridin-3-yl)-2-morpholinoethanamine

HRID 1481354Notes

Reaction equation

HRID 1481354 reaction equation
FC1(F)CC[N:5](C(C2C=CC(C(F)(F)F)=CC=2)CN)[CH2:4]C1.[CH3:22][O:23][C:24]1[N:29]=[CH:28][C:27]([CH:30]=O)=[CH:26][CH:25]=1.[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[CH3:22][O:23][C:24]1[N:29]=[CH:28][C:27]([CH:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH2:4][NH2:5])=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 33645766-Methoxypyridine-3-carbaldehydeHCID 897046912-(4,4-Difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine

Product 1

HCID 897047482-(6-Methoxypyridin-3-yl)-2-morpholinoethanamine

Procedure

This compound was prepared using a method analogous to that of 2-(4,4-difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine (A.2.18), 6-methoxy-pyridine-3-carboxaldehyde replacing 4-(trifluoromethyl)benzaldehyde and morpholine replacing 4,4-difluoropiperidine HCl.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-db33c5cf1fd94a9badcd6123dc680f71
Source dataset
uspto-grants-2016_08
Patent number
US09409917B2

Reaction notes

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