4-Chloro-6-(4-fluorophenyl)pyrimidin-2-amine → N4-[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-6-(4-fluoro-phenyl)pyrimidine-2,4-diamine

HRID 148140Notes

Reaction equation

HRID 148140 reaction equation
[Cl:19][c:20]1[n:21][c:22]([NH2:33])[n:23][c:24](-[c:26]2[cH:27][cH:28][c:29]([F:32])[cH:30][cH:31]2)[cH:25]1.[NH:1]1[CH2:2][CH2:3][c:4]2[c:5]1[n:6][cH:7][cH:8][c:9]2[O:10][c:11]1[c:12]([F:18])[cH:13][c:14]([NH2:17])[cH:15][cH:16]1>>[NH:1]1[CH2:2][CH2:3][c:4]2[c:5]1[n:6][cH:7][cH:8][c:9]2[O:10][c:11]1[c:12]([F:18])[cH:13][c:14]([NH:17][c:20]2[n:21][c:22]([NH2:33])[n:23][c:24](-[c:26]3[cH:27][cH:28][c:29]([F:32])[cH:30][cH:31]3)[cH:25]2)[cH:15][cH:16]1

Participants

3

Reactant 2

HCID 112183534-Chloro-6-(4-fluorophenyl)pyrimidin-2-amineHCID 17979279[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]amine

Product 1

HCID 58733371N4-[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-6-(4-fluoro-phenyl)pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-1f86608f06364741a827f83b2421d24b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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