Dichloromethane → HCID 90011543, compound

Participants

Reaction Steps

Step-5: 1-(6-Nitropyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carbohydrazide: To a (0° C.) cooled solution of step-4 intermediate (2.0 g, 4.80 mmol) in dichloromethane (25 mL) was added drop-wise trifluoroacetic acid (3.70 mL, 48.0 mmol). After stirring the reaction mixture at room temperature for 18 h, the solvent was evaporated under reduced pressure. The crude product was triturated with diethyl ether to obtain 1.32 g (87%) of the title compound as semi solid. The residue was used for next step without further purification. ESI-MS (m/z) 317 (MH)+.

Provenance & Evidence