Sodium Hydroxide → 5-tert-Butyl-4-cyano-2-methyl-2H-pyrazole-3-carboxylic acid

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Reaction Steps

Using the procedure for Example A, Step B above, the title compound was prepared from 5-tert-butyl-4-cyano-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (prepared as described in the previous step, 610 mg, 2.59 mmol) and 1.0 N aqueous NaOH (4.00 mL, 4.00 mmol) in MeOH (10 mL). The title compound was obtained as a white solid. 1H-NMR (400 MHz, CDCl3) δ: 4.17 (s, 3H), 1.45 (s, 9H).

Provenance & Evidence