Boron Trichloride → HCID 71152481, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl ((3aR,5R,6S,7aR)-6-(benzyloxy)-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazol-2-yl)(methyl)carbamate (0.060 g, 0.13 mmol) and PMB (0.10 g, 0.67 mmol) in anhydrous DCM (4 mL) at −78° C. under N2, was added BCl3 (1.0 M in DCM, 0.60 mL, 0.60 mmol). The mixture was stirred for ˜3 h while the temperature of the cooling bath warmed to 0° C. The reaction mixture was cooled at −78° C., quenched with mixed MeOH/DCM, and then concentrated to dryness. The residue was purified on silica gel by flash column chromatography (1.0 M NH3 in MeOH/DCM, 1:12), affording (3aR,5S,6S,7aR)-2-(methylamino)-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazol-6-ol as a white solid (0.030 g, 82%). 1H NMR (400 MHz, CD3OD) δ 6.15 (d, J=6.5 Hz, 1H), 4.38-4.34 (m, 1H), 4.11-4.07 (m, 1H), 4.05-3.98 (m, 1H), 3.68 (dd, J=5.6, 7.1 Hz), 2.84 (s, 3H), 2.20-2.09 (m, 2H); 13C NMR (100 MHz, CD3OD) δ 163.99, 126.24 (q, J=280.7 Hz), 91.08, 75.0 (br.), 72.12 (q, J=29.7 Hz), 70.17, 67.00, 33.65, 30.80; MS, (ES, m/z) [M+H]+ 287.1.

Provenance & Evidence