Trimethyl methanetricarboxylate → HCID 71284563, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-methyl-N-(1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)butylidene)propan-2-amine (1.96 g, ca. 7.2 mmol), prepared according to procedure described in Example 1 Step 6, in diglyme (7 mL) was added trimethyl methanetricarboxylate (2.33 g, 12.2 mmol, 1.7 eq). The reaction was stirred at 160° C. for 4 h then cooled to room temperature. The precipitate was collected by filtration then washed with Et2O to afford the title compound as a yellow solid (150 mg, 0.44 mmol, 6.5% over two steps).

Provenance & Evidence