Acetic Anhydride → HCID 71281758, compound

Participants

Reaction Steps

To a solution of 1-(4-amino-3-hydroxyphenyl)butan-1-one (0.71 g, 4.0 mmol) in CHCl3 (8 mL) was added Ac2O (0.4 mL, 4.2 mmol, 1.06 eq) at 0° C. After 5 min, reaction was quenched with H2O then extracted with CH2Cl2 (3×30 mL). Solvent was removed under reduced pressure to afford N-(4-butyryl-2-hydroxyphenyl)acetamide (0.81 g, 3.7 mmol, 93%) with ca. 80% purity which was used in the next step without further purification.

Provenance & Evidence