Methanol → HCID 86171058, compound

Participants

Reaction Steps

To solution of 3,5-dichloro-6-ethyl-2H-1,4-oxazin-2-one (10.0 g, 52.0 mmol) in DCM (10 mL) was added dry MeOH (10.4 mL, 257 mmol). The reaction was stirred overnight at room temperature. The mixture was purified via column chromatography using EtOAc/hexanes (gradient 0-10%) to afford 5-chloro-6-ethyl-3-methoxy-2H-1,4-oxazin-2-one (4.54 g, 55%) as an oil.

Provenance & Evidence