HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(2-((Dimethylamino)methyl)imidazo[1,2-a]pyridin-6-yl)-5-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 6-(2-((dimethylamino)methyl)imidazo[1,2-a]pyridin-6-yl)-5-ethyl-2-methoxynicotinate | HCID 71284140 | — |
| Product | 6-(2-((Dimethylamino)methyl)imidazo[1,2-a]pyridin-6-yl)-5-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid | HCID 71284813 | 123.3% |
Reaction Steps
Methyl 6-(2-((dimethylamino)methyl)imidazo[1,2-a]pyridin-6-yl)-5-ethyl-2-methoxynicotinate (100.6 mg, 0.27 mmol) was heated with 6 M HCl (1.50 mL) at 80° C. for 3 h. HCl was removed under reduced pressure affording 6-(2-((dimethylamino)methyl)imidazo[1,2-a]pyridin-6-yl)-5-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (113.3 mg) as dihydrochloride salt in 99% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409905B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-850f19fd971841a1b4808cdb65d2dc9a |
| Source note | uspto-grants-2016_08 |