反应详情

To solution of methyl 5-ethyl-6-(5-(hydroxymethyl)-6-methyl-6H-thieno[2,3-b]pyrrol-2-yl)-2-methoxynicotinate (0.233 g, 0.75 mmol) in DCM (8 mL) was added activated MnO2 (0.60 g+0.60 g+0.30 g, 6.20+6.20+3.10 mmol) in 3 portions with 30 min intervals. Reaction was monitored by LC/MS. Upon complete consumption of starting material MnO2 was filtered and washed with DCM. Mother liquor was concentrated affording methyl 5-ethyl-6-(5-formyl-6-methyl-6H-thieno[2,3-b]pyrrol-2-yl)-2-methoxynicotinate (0.192 g, 82%) as solid.

1. customReaction
2. customUpon complete consumption of starting material MnO2
3. filtrationwas filtered
4. washwashed with DCM
5. concentrationMother liquor was concentrated