HCID 71281757, compound → HCID 71281824, compound

Participants

Reaction Steps

Solution of 1-benzyl 4-tert-butyl 2-(5-(3-ethyl-6-methoxy-5-(methoxycarbonyl)pyridin-2-yl)-1-methyl-1H-indol-2-yl)piperazine-1,4-dicarboxylate (71.4 mg, 0.11 mmol), prepared according to procedure described in Example 67, Step 3, in MeOH (1 mL) was hydrogenated over Pd/C (10% Degussa type, 10 mg) with H2-balloon. After 1 h complete consumption of starting material was observed. Catalyst was filtered and washed with MeOH (5 mL). Concentration of mother liquor afforded tert-butyl 3-(5-(3-ethyl-6-methoxy-5-(methoxycarbonyl)pyridin-2-yl)-1-methyl-1H-indol-2-yl)piperazine-1-carboxylate which was used directly in the next step. LC-MS 509.3 [M+H]+, RT 1.28 min.

Provenance & Evidence