Dimethyl methoxymethylenemalonate → HCID 71285326, compound

Participants

Reaction Conditions

Reaction Steps

N-(1-(2-((tert-butyldimethylsilyloxy)methyl)-1-methyl-1H-indol-5-yl)butylidene)-1-(2,4-dimethoxyphenyl)methanamine (5.94 g, 12.0 mmol), prepared according to procedure described in Example 164 Step 1, was suspended in Ph2O (20 mL) then dimethyl 2-(methoxymethylene)malonate (3.55 g, 20.4 mmol, 1.7 eq) was added. The reaction mixture was heated to 190° C. for 1 h before mixture was cooled to room temperature then purified by flash column chromatography (0-50% EtOAc in CH2Cl2) to give the title compound. LC-MS 605.5 [M+H]+, RT 1.75 min.

Provenance & Evidence