Tetrabutylammonium Fluoride → HCID 71285152, compound

Participants

Reaction Steps

To a suspension of methyl 6-(1-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-7-yl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate (1.4 g, 3.0 mmol) in THF (20 mL) was added a solution of TBAF (3.2 mL, 1M, 3.2 mmol) in THF. The reaction mixture was stirred at room temperature for 1 h and then concentrated. The crude residue was triturated with THF to afford the title compound as an off-white solid (0.9 g, 80%).

Provenance & Evidence