HCID 71285150, compound → HCID 71284398, compound

Participants

Reaction Steps

To a solution of 2,4-bis(benzyloxy)-6-(3-cyano-1-methyl-1H-indol-5-yl)-5-ethylnicotinic acid (123 mg, 0.24 mmol) in EtOAc (4 mL) was added Pd/C (10% Degussa type, 30 mg) at room temperature. The flask was evacuated then back-filled with H2 (1 atm) over three cycles. The reaction was monitored by LC-MS. Upon completion, the reaction mixture was filtered through celite then washed with MeOH (ca. 25 mL) thoroughly. The filtrated was concentrated to afford the title compound (58 mg, 72%).

Provenance & Evidence