Potassium Carbonate → HCID 71284744, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2,4-bis(benzyloxy)-6-(2-chloro-3-cyano-1-methyl-1H-indol-5-yl)-5-ethylnicotinate (143 mg, 0.25 mmol) in DMF (2 mL) was added potassium carbonate (70 mg, 0.50 mmol, 2.0 eq) followed by pyrrolidine (0.05 mL, 0.61 mmol, 2.4 eq) at room temperature. The reaction was heated to 60° C. and the progress was monitored by LC-MS. Upon completion, the reaction was quenched with water then extracted with EtOAc (3×25 mL). The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography (0-10% EtOAc in 1/1 CH2Cl2/hexanes) to afford the title compound (134 mg, 89%).

Provenance & Evidence