Formaldehyde → HCID 71284724, compound

Participants

Reaction Steps

The product of Step 1 (710 mg, 2 mmol) was suspended in 1,2-dichloroethane with formaldehyde (0.4 mL of 37% aqueous solution, 5 mmol). Sodium triacetoxyborohydride (848 mg, 4 mmol) was added to the mixture. The mixture stirred vigorously at room temperature for 30 min. The mixture was washed with aqueous saturated NaHCO3 and run through a plug of silica gel, eluting with EtOAc, to give the product (690 mg, 90%).

Provenance & Evidence