Potassium Hydroxide → HCID 90010802, compound

Participants

Reaction Conditions

Reaction Steps

A 25 mL 3-neck flask was equipped with a magnetic stirrer, a reflux condenser with nitrogen blanket, and a heating mantle with a temperature controller and a thermocouple. The flask was charged with 1.12 grams (0.0033 moles) of 4-tritylphenol, 0.22 grams (0.0033 moles, 85 wt. %) of potassium hydroxide pellets, and with 5 mL of dimethylsulfoxide. The mixture was stirred under nitrogen while heating to 100° C. After about 2 hours, all of the potassium hydroxide had dissolved, and the mixture was cooled to 70° C. 6-Chlorohexanol (0.45 grams, 0.0033 moles) was then added in one portion. The reaction mixture was maintained at 100° C. for about 0.5 hours, then it was stirred at room temperature overnight. A sample withdrawn for GC analysis at this point showed no remaining starting materials, indicating that the reaction was completed. The reaction mixture was poured into 100 mL of water. Solids precipitated. The mixture was filtered. The beige solids were washed on the filter with several portions of water, then they were air-dried. The yield of product was 1.2 grams (83%). The structure was confirmed by IR, 1H- and 13C-NMR, and GC/MS analyses.

Provenance & Evidence