HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 2-(3-methyl-1H-indazol-1-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Fluorobenzonitrile | HCID 67855 | — |
| Reactant | HCID 178434273 | HCID 178434273 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ammonium Chloride | HCID 25517 | — |
| Product | 2-(3-methyl-1H-indazol-1-yl)benzonitrile | HCID 90037545 | 89.3% |
Reaction Steps
Cs2CO3 (1.56 g, 4.8 mmol) was added to a solution of 3-methyl indazole (0.634 g, 4.8 mmol) and 2-fluorobenzonitrile (1 mL, 9.6 mmol) in DMF (20 mL). After 12 h the mixture was diluted with sat. NH4Cl and a precipitate formed. The solid was filtered, washed with H2O, hexane and dried under vacuum to give 2-(3-methyl-1H-indazol-1-yl)benzonitrile (1 g, 89%) which was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409888B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-3945abfd7b1341d89b985353e7562b8f |
| Source note | uspto-grants-2016_08 |