Dimethylformamide → HCID 90221230, compound

Participants

Reaction Steps

To an ice cold solution of (S)-3-(2-amino-5-cyano-phenylamino)-2-tert-butoxycarbonyl amino-propionic acid (4.1 g, 12.812 mmol) in DMF (40 mL) was added EDCI.HCl (2.89 g, 15.125 mmol), HOBT (2.05 g, 15.125 mmol) and DIPEA (7.1 mL, 41.25 mmol). The resulting mixture was stirred for 16 h at RT and mixture was diluted with ethyl acetate and washed with water, brine and the organic solution was concentrated to give a material which was purified by silica gel chromatography to afford the title compound (1.4 g, 36.26%) as a light pink solid. LC-MS: 303.2 (M+H).

Provenance & Evidence