Hydrochloric Acid → HCID 90220939, compound

Participants

Reaction Steps

To a solution of [(S)-7-cyano-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester (Intermediate 9) (400 mg, 0.877 mmol) in 1,4 dioxane (3 mL) at 0° C. was added 4 N HCl in dioxane solution (0.7 mL) dropwise. The mixture was stirred for 16 h at RT. The mixture was concentrated and the residue was triturated with diethyl ether to provide (S)-3-amino-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbonitrile hydrochloride (310 mg, 90.15%) obtained as an off white solid. LC-MS: 357.2 (M+H).

Provenance & Evidence