反应详情

To a solution of (2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(R)-(1,2,3,4-tetrahydro-naphthalen-1-yl)carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (Intermediate 21) (9.5 g, 16.35 mmol) in DCM (50 mL) at 0° C. was added TFA (49 mL, 654.045 mmol) dropwise and the cooling bath removed. After 16 h the mixture was concentrated and the residue was triturated with ether to provide the title compound as an off white solid (9.55 g). LC-MS: 482 (M+H).

1. customthe cooling bath removed
2. concentrationAfter 16 h the mixture was concentrated
3. customthe residue was triturated with ether