Acetyl chloride → HCID 118677393, compound

Participants

Reaction Steps

To tert-butyl N-[(1S)-2-[[(1S)-2-[(2S,4S)-2-(benzylcarbamoyl)-4-[[4-[(3S)-5-[(6-bromo-2-methoxy-1-naphthyl)methyl]-3-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzodiazepine-1-carbonyl]benzoyl]amino]pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-N-methyl-carbamate (45 mg, 0.035 mmol) in methanol (2 mL) at room temperature was added acetyl chloride (25 μL, 0.035 mmol) dropwise. The mixture was allowed to stand at room temperature. After 16 h the mixture was concentrated and the residue was triturated with acetonitrile to give the title compound (40 mg, 98%) as a tan solid. MS: m/z 1085 (MH+)

Provenance & Evidence