Hydrochloric Acid → HCID 90221442, compound

Participants

Reaction Steps

To a solution of tert-butyl N-[(1S)-2-[[(3S)-5-[(5-bromo-2-methoxy-1-naphthyl)methyl]-1-[4-[(3S)-5-[(5-bromo-2-methoxy-1-naphthyl)methyl]-3-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzodiazepine-1-carbonyl]benzoyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-oxo-ethyl]-N-methyl-carbamate (50 mg, 0.037 mmol) in dioxane (1 mL) at 0° C. was added 4 M HCl in dioxane (0.6 mL) dropwise and the cooling bath removed. After 3 h the mixture was evaporated and the residue was triturated with hexane to afford the title compound (35 mg, 77.2%) as a white solid. LC-MS: 1153.2 (M+H).

Provenance & Evidence