Terephthaloyl chloride → HCID 90221050, compound

Participants

Reaction Steps

In a similar manner to that described for Example 22, terephthaloyl chloride (60 mg, 0.296 mmol) and methyl-{(S)-1-[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester (Intermediate 15) (305.37 mg, 0.591 mmol) were converted to the title compound (50 mg) as an off white solid. LC-MS: 963.6 (M+H).

Provenance & Evidence