Hydrochloric Acid → HCID 118677395, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl N-[(1S)-2-[[(3S)-5-[4-[(3S)-3-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]propanoyl]amino]-7-cyano-1-[(2-methyl-1-naphthyl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepine-5-carbonyl]benzoyl]-7-cyano-1-[(2-methyl-1-naphthyl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-oxo-ethyl]-N-methyl-carbamate (27 mg, 0.022 mmol) in dioxane (3 mL) at 0° C. was added 4 M HCl in dioxane (2 mL). The mixture was stirred at 0° C. for 10 min, and the cooling bath was removed. After 16 h, the mixture was concentrated and the residue was triturated with diethyl ether to afford the title compound as a white solid (19 mg, 78.69%). LC-MS: 1013.8 (M+H).

Provenance & Evidence