Acetyl chloride → HCID 118677384, compound

Participants

Reaction Steps

tert-Butyl N-[(1S)-2-[[(3S)-5-[(6-bromo-2-methoxy-1-naphthyl)methyl]-1-[4-[(3S)-5-[(6-bromo-2-methoxy-1-naphthyl)methyl]-3-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzodiazepine-1-carbonyl]benzoyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-oxo-ethyl]-N-methyl-carbamate (24 mg, 0.018 mmol) and acetyl chloride (6.3 μL, 0.089 mmol) were combined in MeOH (2 mL) and stirred at room temperature overnight. The mixture was concentrated and the residue triturated with acetonitrile to give the title compound (18.3 mg, 84%) as a solid. LC-MS: 1149 [M−H].

Provenance & Evidence