反应详情

温度

60 °C

To a solution of (S)-ethyl 5-(4-(but-3-en-1-yl)-4-methylpiperidin-1-yl)-6-(1-(tert-butoxy)-2-methoxy-2-oxoethyl)-7-methylimidazo[1,2-a]pyridine-2-carboxylate (0.164 g, 0.328 mmol, 1 equiv) in MeOH (3.3 mL) was added 1 N NaOH (0.36 mL, 0.36 mmol, 1.1 equiv). After stirring 18 h, the reaction was heated to 60° C. for 2 h. Upon cooling to ambient temperature, the reaction was concentrated in vacuo. The residue was then concentrated in vacuo with toluene (×3) to remove residual MeOH to provide the product as a yellow solid (0.168 g, 100%). LCMS (ESI, M+1): 472.3.

1. temperatureUpon cooling to ambient temperature
2. concentrationthe reaction was concentrated in vacuo
3. concentrationThe residue was then concentrated in vacuo with toluene (×3)
4. customto remove residual MeOH